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KMID : 0613820200300020191
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Journal of Life Science
2020 Volume.30 No. 2 p.191 ~ p.201
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Harmfulness of Particulate Matter in Disease Progression
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Choi Jong-Kyu
Choi In-Soon
Cho Kwang-Keun
Lee Seung-Ho
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Abstract
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As society develops rapidly, environmental pollution is becoming a greater risk factor threatening human health. One of the major causes of air pollution that affects human health is particulate matter (PM), which contains a heterogeneous mixture of different particle sizes and chemical compositions. PM is classified by size into general PM (PM10; diameter below 10 μm) and fine PM (PM2.5; diameter below 2.5 μm). PM2.5 can pass through the respiratory tract into the circulatory system and thence throughout the body. PM2.5 is known to stimulate oxidative stress and inflammatory responses to cells, promoting diseases such as asthma, chronic respiratory disease, cardiovascular disease, diabetes mellitus, and immunological disorders. Although detailed molecular mechanisms for how PM stimulates disease progression still need to be elucidated, together with national efforts to reduce PM production, significant research has been conducted that demonstrates the harmfulness of PM in disease progression through in vitro and in vivo experiments. This review focuses on the harmfulness of PM in disease progression; we also introduce a biological verification method for determining the hazards of PM.
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KEYWORD
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Fine particulate matter, particulate matter, respiratory disease
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